SOCIETY OF TOXICOLOGY 2024 HOSTED SESSION SUMMARY
SCIREQ & the Fraunhofer ITEM hosted a free in-person session at the Society of Toxicology 2024.
Session Description: During this session, speakers will examine critical factors for robust and reliable in vitro and in vivo aerosol exposure studies with inhaled therapeutics and with airborne toxicants such as e-cigarettes. The speakers will discuss the importance of establishing correlations between in vitro and in vivo outcomes, and explore the respective strengths and limitations of mouse and airway-liquid interface (ALI) models.
Talks:
Application of PRIT ExpoCube system for inhalation PBPK modeling – use case for an inhalable agent
- Dr. Katharina Schwarz, leads the department “Aerosol Technology and Aerosol Biophysics” at the Fraunhofer ITEM.
Studying thirdhand vaping exposures using the inExpose system – Exposure Assessment and Biological Characterization
- Dr. Patricia Silveyra: Associate Professor and Chair of the Department of Environmental and Occupational Health at Indiana University Bloomington School of Public Health.
- Dr. Sarah Commodore: Assistant Professor in the Department of Environmental and Occupational Health in the School of Public Health at Indiana University Bloomington. hos
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Speaker Spotlight
Dr. Katharina Schwarz
Dr. Katharina Schwarz leads the department “Aerosol Technology and Aerosol Biophysics” at the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) in Hannover, Germany. She has a doctoral degree in mechanical process engineering with about 15 years of experience in the field of biophysical particle-lung interaction and conduct of toxicological, pre-clinical and clinical studies. She has a strong expertise at the interface between aerosol/inhalation research, respiratory pharmacokinetics, toxicology/physiology, and exposure science.
Currently, the special research interests are in the field of characterization of the sources of potentially harmful airborne substances (external dose), their spreading/dispersion and transformation, the characterization of human exposure at workplaces and to consumers, and uptake and distribution in the organism (internal dose). This includes development and evaluation of exposure modelling concepts, development of an inhalation-focused PBK model as well as quantitative in vitro to in vivo extrapolation (QIVIVE) in cooperation with the departments Preclinical Pharmacology, In Vitro Toxicology and In Silico Toxicology.
Since 2019 she is one of the chairs of the working group Environmental/Occupational Health/Toxicology of the International Society for Aerosols in Medicine.
Dr. Patricia Silveyra
Dr. Patricia Silveyra is an Associate Professor and Chair of the Department of Environmental and Occupational Health at Indiana University Bloomington School of Public Health. Her research focuses on the study of sex differences and the role of sex hormones and their receptors in mechanisms of lung inflammation. She uses a combination of in vivo and in-vitro models to assess the effects of environmental exposures such as air pollutants, allergens, and vapes in both the healthy and diseased lung (including asthma and lung cancer), with special consideration of sex as a biological variable.
Dr. Sarah Commodore
Sarah Commodore is an Assistant Professor in the Department of Environmental and Occupational Health in the School of Public Health at Indiana University Bloomington. The focus of Dr. Commodore’s research program is to understand how environmental pollutants influence molecular mechanisms in the developing and compromised (diseased) lungs. She is particularly interested in understanding how exposures to vaping products influence molecular mechanisms involved with 1) in utero development of the lungs, and 2) inflammatory responses during critical developmental and disease windows.
In Vivo and In Vitro Smoke Exposure
We are proud to introduce the commercialized expoCube, adding robust in vitro exposure to the automated inExpose system.
The expoCube provides a novel ALI (air liquid interface) culture exposure system, integrating with the inExpose’s existing exposure generators such as the integrated cigarette smoking robot and industry leading e-cigarette extensions.
The expoCube features:
- Reproducibility: Efficient, uniform, and precise exposure of particulates onto target cells and tissues.
- Precision: Optimized flow paths using advanced computational fluid dynamics (CFD) modelling.
- Deposition: Patented thermophoresis, increasing the deposition efficiency of small particles without imparting unnatural electrostatic charges onto the aerosols.
No cal? No problem! Using Noninvasive Impedance to Assess Respiratory Function
Hosted Session – March 12th, 2024, 12-1pm MST, Room 155 C
emka TECHNOLOGIES will be hosting a free in-person session on March 12th. The event will be held at the SOT 2024 Conference Room in Room 155C. Space is limited so please register to ensure your seat.
Session description: The presentation will discuss evaluation of noninvasive impedance device for respiratory assessment using emkaPACK Jacketed Telemetry System. Through standard external ECG leads both ECG and external respiratory impedance data will be compared against the proven RIP system using positive control agents. Additionally, calibration stability will be evaluated over time through pre and post calibration checks. Finally, the presentation will demonstrate methods of recovering data in the event of inaccurate pneumotach calibrations using scaling utilities within ECG auto.