Phenotyping and genetic studies of animal models are an important tool for pre-clinical research to learn more about gene function in humans. A single gene can have a different impact and function across multiple organ systems or time points during development. Therefore, the phenotyping process must be highly standardized to enable appearance of certain phenotypes that would otherwise remain hidden. Phenotypes for genetic study must consistently meet high standards of reproducibility and validity.
Translational research is increasingly important and necessary to better understand disease pathologies. The flexiVent offers precise measurement of lung function in mouse models, which can be used as an initial screen for potential pulmonary phenotypes. These measurements are extremely sensitive and reproducible manoeuvres, which allow small but significant changes to be assessed and offer information about lung structure.
Disease models are often generated by exposing subjects to aerosols, smoke, or vapour using acute or chronic protocols to establish relevant phenotypes. The inExpose has been specifically designed to allow for repetitive precise delivery of the test atmosphere through automated exposure profiles, which also help to reduce user error and minimize outcome variations among subjects, study, and research groups. The inExpose operates under various configurations and protocols to ensure that the subjects receive repeated yet consistent exposure environments throughout experimentation. Generating relevant, practical animal models is key for translating the outcomes from the preclinical environment into a better understanding of disease pathologies
Whole body plethysmography permits a continuous and non-invasive assessment of breathing patterns in conscious subjects. Measurements of respiratory rate, estimated tidal volume, minute ventilation and events like apneas and deep sighs provide valuable insights into the subject’s breathing drive and behavior. Genetic studies using plethysmography techniques evaluate the effects of various genes on breathing control and activity and are often used for screening purposes.
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