Read SCIREQ’s most popular blog posts about lung function measurement
1. Measuring Dynamic Compliance and Static Compliance
Dynamic compliance of the respiratory system is obtained with the SnapShot perturbation, which studies the lung under conditions of tidal breathing.
2. FIRST IDIOPATHIC PULMONARY FIBROSIS MOUSE MODEL
Recent study (Nureki SI, et al) succeeded to develop the first idiopathic pulmonary fibrosis mouse model. Lung function measurements were performed with the flexiVent.
3. Circadian Rhythm effects lung function
Measuring the effects of the circadian rhythm on the lung requires the highest possible sensitivity to capture crucial details about the mechanical properties of airways. The flexiVent is able to measure mechanics of the lungs as a whole, and partition between central vs. peripheral airways. Moreover its automated dose-response feature permits an unparalleled level of insight into lung function throughout the progression of inflammation, infection, or disease development.
4. WHAT YOU ALWAYS WANTED TO KNOW ABOUT SPECIFIC AIRWAY RESISTANCE
Specific airway resistance (sRaw), or its reciprocal specific airway conductance (sGaw), was first introduced over 35 years ago as a way to gather information on airflow resistance in conscious subjects during quiet spontaneous breathing.
5. QUICKPRIME MEASUREMENTS FOR DEEPER INSIGHT
Broadband forced oscillation technique measures a subject’s response to a signal containing a wide range of frequencies; providing the best study insights.
6. Inhalation Exposure System for Nicotine Delivery
Study with inhalation exposure systems such as the inExpose provides evidence about clinical effects of nicotine delivery by traditional and new methods.
7. Longitudinal Studies with the flexiVent
The flexiVent performs repeat measurements when using intubation, allowing researchers to conduct longitudinal studies and acquire detailed lung mechanics information. There are many published studies performed with the flexiVent that highlight longitudinal studies with mice, rats, and guinea pigs via tracheal intubation, with just a small sampling listed below.
8. Pulmonary Hypertension Animal Models
Preclinical study validated novel pulmonary hypertension animal models. The group was able to access specific lung functions using the flexiVent.
9. To open or close the lungs – that is the question!
The two most common and greatly contrasting methods, to study respiratory diseases include open lung- and closed lung-approaches. This has led to many pulmonary researchers conducting experiments with the goal of determining which approach is the least harmful and the best possible way to minimize ventilator-induced lung injury (VILI).
10. Upper airway resistance measurements with the flexiVent
While the flexiVent is typically utilized to assess the mechanical properties of the lower airways, it can also be used for accurate measurements of nasal obstruction. As previously reported in respected scientific journals, this approach provides a means to reliably and directly assess upper airway resistance in disease models.