SCIREQ is excited to attend the American Association of Immunologists (AAI) meeting for the first time in San Diego from May 9-13, 2019. At AAI we will focus on Infectious Respiratory Diseases Research and how our respiratory systems can enhance preclinical studies.
Infectious respiratory diseases are caused by pathogenic microorganisms that can affect the upper and lower airways in an acute or chronic manner. Respiratory infections can range in severity from symptoms of sneezing, coughing and excess mucous production to airway hyperresponsiveness, airflow obstruction or alterations in normal gas exchange. These lead to impaired lung function caused by pulmonary edema formation, collapse of lung areas, poor blood oxygenation, and enhanced breathing efforts.
What do our pulmonary systems do?
SCIREQ’s respiratory systems provide complete characterization of respiratory mechanics. They also allow a full analysis of respiratory disease progression for various infectious disease models.
How does the flexiVent fit in?
The flexiVent can assess the respiratory system mechanics such as overall resistance and compliance, heterogeneities of the lung, central vs. peripheral mechanics, static compliance, as well as providing most clinically-relevant outcomes such as forced expiratory volumes (FEV) and additional lung volume information. As respiratory infection induces airway hyperresponsiveness and mucus hypersecretion. The flexiVent can deliver aerosol challenges to a subject’s lungs and follow the developing bronchoconstriction through automated data collection.
How does the inExpose fit in?
The inExpose administers drugs and novel therapeutic carriers through the inhalation pathway, a preferential route for preclinical models. It standardizes experimental conditions providing reproducible and relevant animal models.
How does the vivoFlow fit in?
The vivoFlow whole body plethysmograph tracks changes in ventilatory parameters throughout the progression of a respiratory infection. This technique provides continuous high-fidelity respiratory recordings including measures of respiratory rate, estimated minute ventilation, tidal volumes.
Applications for infectious respiratory diseases research
Influenza A virus (IAV)
IAV has multiple strains that can cause a variety of symptoms in its host. Consequently, the virus leads to morbidity and mortality as well as inflammation and mucus in the upper and lower respiratory tract. Research today is targeted on understanding the pathogenesis of the virus and identifying mechanisms of protection and treatment.
- Eunice, E. et al. (2019). Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice. Scientific Reports. 2366(2019)
Respiratory syncytial virus (RSV)
RSV causes lower respiratory infections across all ages with infants and children have an increased risk of infection. RSV research focuses on understanding how the virus infects a host, causes clinical disease, and how to mitigate symptoms of the virus in order to reduce disease incidence and hospitalizations.
- Maltby, S., at al. (2017). Identification of IFN-ʏ and IL-27 as critical regulators of respiratory syncytial virus- induced exacerbation of allergic airways disease in a mouse model. The Journal of Immunology. 200(237)
Pneumonia can be a bacterial, viral, or fungi infection that causes inflammation in the alveoli of the lung. It is associated primarily with concurrent infections leading to high rates of morbidity and mortality. Some of the examples are Influenza, airway hypersensitivity, and acute respiratory distress syndrome. Research is aimed at identifying high-risk targets and pathogenic relationships at both the molecular and physiological level.
- Totten A.H., et al. (2018). Allergic airway sensitization impairs antibacterial IgG response during bacterial respiratory tract infections. Journal of allergy and Clinical Immunology
Visit us at our booth during Immunology 2019
Immunology 2019 San Diego, California
Exhibit Dates / Hours:
May 10-12, 2019: 9:30 – 16:30