Current use of inhalation exposure systems
So far only a few studies use computerized inhalation exposure systems for nicotine delivery. Instead many preclinical researchers investigate the effects of nicotine through intraperitoneal injections or oral consumption. Since the effects on the central nervous system (CNS) can depend on the method of administration, traditional methods of nicotine delivery such as cigarette smoke and e-cigarette vapor inhalation, provide relevant translational outcomes for clinical investigations.
Study investigates existing inhalation exposure systems
Dr. Alasmari and Dr. Crotty Alexander from the College of Pharmacy and Pharmaceutical Sciences of the University of Toledo and the Pulmonary and Critical Care Section of the San Diego Health Care System Institutions investigated the delivery of e-cigarette vapor and tobacco smoke through computerized machines. In addition to that, they compared the efficiency and practical applicability of the inExpose system to other nicotine inhalation systems.
Alasmari, Fawaz, et al.¹ study outcomes showed:
- Evidence that validates inhalation exposure systems as a more clinically relevant method of nicotine delivery compared to other delivery routes.
- Benefits of computerized inhalation exposure systems in terms accuracy and exposure parameters flexibility.
- The inExpose efficiently delivering high concentrations of nicotine into the brain through inhalation. Brain and plasma cotinine concentration in mice following six months of e-cigarettes exposure parallels human active smokers, validating inhalation exposure as a method for nicotine delivery into the circulatory system.
INEXPOSE – PROVIDING RELEVANT AND REPRODUCIBLE INHALATION EXPOSURE MODELS
Due to its precise control over the exposure, the inExpose allows researchers to finely-tune experiments to mimic real-world conditions providing relevant and practical animal models, which can be reproduced by collaborators globally.
¹Alasmari, Fawaz, et al. “A computerized exposure system for animal models to optimize nicotine delivery into the brain through inhalation of electronic cigarette vapors or cigarette smoke.” Saudi pharmaceutical journal (2018).