In Applications, Conferences & Events, flexiVent

What is Bronchopulmonary Dysplasia?

Bronchopulmonary dysplasia (BPD) is a pediatric respiratory disorder that affects preterm infants who experienced respiratory distress. The distress can be treated with artificial surfactant administration and hyperoxia which leads to impaired growth of the lung due. BPD will begin to manifest as inflammation and vascular changes in the lungs¹.

 

BPD study with Whole Body Plethysmography.

Plethysmography for INFECTIOUS RESPIRATORY DISEASESA common model of preclinical BPD uses hyperoxic exposure an early stage of life to alter the development of the subject’s lungs. Using conscious, unrestrained term or preterm subjects in a whole body plethysmography chamber allows for longitudinal measurements of ventilatory parameters, while also enabling controlled mixing and delivery of gases to generate a reproducible hyperoxic environment. Whole body plethysmography provides an ideal set-up to generate a model and track changes in the ventilatory parameters simultaneously.

 

 

BPD study with the flexiVent.

flexiVent INFECTIOUS RESPIRATORY DISEASESHyperoxia induced BPD leads to airway remodeling and airway hyperresponsiveness in early adulthood². Changes in the tissue properties of the subject can reflect changes due to the effects of hyperoxia on lung development³. The flexiVent is a small animal ventilator that measures detailed respiratory mechanics. With the use of an integrated nebulizer, automated dose responses capturing the mechanical properties of the lung can separate naïve and BPD subjects, and potentially show separation within the treated groups due to disease severity. Once exposed to hyperoxia at early stages of life, subjects are more likely to develop pulmonary hypertension as the changes in lung growth add strains on the cardiovascular system4. By measuring right ventricular pressure (RVP) through catheterization and quantifying the Pressure-Volume (PV) loops of the RVP, the severity of the associated pulmonary hypertension can be measured.

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