In Applications, inExpose, Publications

Congratulations to Dr. Blackwell’s team at Vanderbilt University who recently published in Nature Communications1!

As you may know, chronic obstructive pulmonary disease (COPD) is characterized by obstruction in airflow, chronic inflammation, and destruction of the alveolar tissue. This group from Vanderbilt University hypothesized that secretory immunoglobulin A (SIgA) deficiency contributes to chronic airway inflammation and COPD disease progression.

The SCIREQ inExpose was utilized in multiple ways to gather evidence to support their theory. First, using the inExpose to deliver cigarette smoke, researchers confirmed that (SIgA) knock-out mice spontaneously develop COPD-like symptoms with similar severity to cigarette smoke exposed subjects.

Next, a lysate from a non-typeable Haemophilus influenza (NTHi), which is commonly found in COPD patients, was prepared as an aerosol solution and delivered using the inExpose to both wild-type and knock-out mice. The group then re-introduced SIgA and found an attenuated inflammatory response, suggesting SIgA limits the response to bacterial antigens in the respiratory system.

To learn more and read the full publication, visit Nature Communications’ website at www.nature.com/ncomms/2016/160405/ncomms11240/

Whether through smoke or aerosol, nose-only or whole body exposure, the inExpose easily adapts to various toxicology research needs by permitting relevant and reproducible inhalation exposure models. To learn more on this product, please visit our website at www.scireq.com/inexpose.

1Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
Richmond BW et al. Nat Commun. 2016 Apr 5;7:11240. doi: 10.1038/ncomms11240.

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