Respiratory Mechanics & Lung Function

Measurements of respiratory mechanics and lung function are crucial and invaluable tools for many areas of basic and pre-clinical pharmacological pulmonary research as they provide a direct measure of the acute or chronic disease-related changes to the lungs.

Challenges

  • Measuring respiratory mechanics and lung function in subjects as small as a mouse is not trivial. Traditional measurement techniques often cannot be scaled down to rodent size without loss of accuracy. Mechanics parameters also vary with experimental conditions such as frequency and tidal volume.

  • In addition, a trade-off referred to as the Phenotyping Uncertainty Principle exists between the non-invasiveness of a measurement technique and its precision. The less invasive a measurement, the less likely it is to produce consistent, reproducible and meaningful data.

SCIREQ Solution

  • With the flexiVent, SCIREQ has created a unique, integrated platform that allows scientists to efficiently and reproducibly measure detailed respiratory mechanics literally at the push of a button. The flexiVent is designed to achieve the best possible measurement accuracy and detail in anaesthetized subjects ranging from under 10 g up to 40 kg.

  • The flexiVent is also highly useful for preclinical thoracic imaging. The flexiVent's ability to provide breath hold manoeuvres and accurate gating dramatically enhances image quality, and the ability to obtain simultaneous measurements of lung structure and function provides exciting research opportunities.