Organ Transplant & Regeneration
The prevalence of lung transplants has increased over the past 30 years as it has become a practical option for numerous lung diseases, doubling over the past decade. One of the main limiting factors to lung transplants is the viability of the transplanted lung, with only 15% of donor lungs being harvested in contrast to hearts harvested at 30% and livers and kidneys at 80%.
Harvested lungs are susceptible to trauma in death and during transport and handling, with high incidences of infection, pneumonia and ventilator-induced lung injury (VILI) once implanted. These sensitivities necessitate better screening of the lungs in vivo and ex vivo and careful monitoring following a successful transplant.